Users are recommended (by US-CERT) to take the following actions to remediate Simda (and other) infections:
Use and maintain anti-virus software - Anti-virus software recognizes and protects your computer against most known viruses. It is important to keep your anti-virus software up-to-date (see Understanding Anti-Virus Software for more information).
Change your passwords - Your original passwords may have been compromised during the infection, so you should change them (see Choosing and Protecting Passwords for more information).
Keep your operating system and application software up-to-date - Install software patches so that attackers cannot take advantage of known problems or vulnerabilities. Many operating systems offer automatic updates. If this option is available, you should enable it (see Understanding Patches for more information).
Use anti-malware tools - Using a legitimate program that identifies and removes malware can help eliminate an infection. Users can consider employing a remediation tool (examples below) that will help with the removal of Simda from your system.